Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana |
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Authors: | Qiang Ding Li-Xin Yang Hai-Wei Yang Chao Jiang Yi-Fen Wang Shui Wang |
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Institution: | 1. Department of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China;3. Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, China;4. Clinical Research Center, the First Affiliated Hospital of Nanjing Medical University, China |
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Abstract: | Ethnopharmacological relevanceThe roots and rhizomes of Clematis are commonly used as an analgesic, abirritative, antibacterial, antiphlogistic, anticancer and diuretic agent. The Naxi people traditionally used Clematis ganpiniana's (Lévl. Et Vant.) as a diuretic agent, an anti-inflammatory and anticancer remedy.Aim of studyTo investigate the cytotoxic and antibacterial components from Clematis ganpiniana.Materials and methodsThe aboveground part of Clematis ganpiniana was isolated by chromatographic techniques. Structures of isolated compounds were identified by spectroscopic methods and comparison with published data. Their cytotoxic, apoptosis and antibacterial activities of purified components were also performed.ResultsBy bioassay-guided fractionation techniques and chemical characterization, four triterpene glycosides were isolated and their cytotoxicity against cancer cells and antibacterial activity were tested. They showed significant inhibitory activities against MCF-7, MDA-MB-231 with IC50 value of 0.7–16.5 μg/ml, and significant apoptosis for MCF-7 and MDA-MB-231. Moreover, compound 4 showed weak wide-spectrum antibacterial activity.ConclusionThese results provide promising baseline information for the potential use of Clematis ganpiniana as well as some of the isolated compounds in the treatment of cancer and infectious disease. |
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Keywords: | Clematis Triterpenoids Antibacterial activity Cytotoxicity |
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