Rosewood oil induces sedation and inhibits compound action potential in rodents |
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Authors: | Reinaldo Nóbrega de Almeida Demétrius Antonio Machado Araújo Juan Carlos Ramos Gonçalves Fabrícia Costa Montenegro Damião Pergentino de Sousa José Roberto Leite Rita Mattei Marco Antonio Campana Benedito José Gilberto Barbosa de Carvalho Jader Santos Cruz José Guilherme Soares Maia |
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Institution: | 1. Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba (LTF/UFPB), 58051-900 João Pessoa, PB, Brazil;2. Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), 04023-000 São Paulo, SP, Brazil;3. Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, 31901-970 Belo Horizonte, MG, Brazil;4. Faculdade de Engenharia Química, Universidade Federal do Pará (FEQ/UFPA), 66075-900 Belém, PA, Brazil |
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Abstract: | Aim of the studyAniba rosaeodora is an aromatic plant which has been used in Brazil folk medicine due to its sedative effect. Therefore, the purpose of the present study was to evaluate the sedative effect of linalool-rich rosewood oil in mice. In addition we sought to investigate the linalool-rich oil effects on the isolated nerve using the single sucrose-gap technique.Materials and methodsSedative effect was determined by measuring the potentiation of the pentobarbital-induced sleeping time. The compound action potential amplitude was evaluated as a way to detect changes in excitability of the isolated nerve.ResultsThe results showed that administration of rosewood oil at the doses of 200 and 300 mg/kg significantly decreased latency and increased the duration of sleeping time. On the other hand, the dose of 100 mg/kg potentiated significantly the pentobarbital action decreasing pentobarbital latency time and increasing pentobarbital sleeping time. In addition, the effect of linalool-rich rosewood oil on the isolated nerve of the rat was also investigated through the single sucrose-gap technique. The amplitude of the action potential decreased almost 100% when it was incubated for 30 min at 100 μg/ml.ConclusionsFrom this study, it is suggested a sedative effect of linalool-rich rosewood oil that could, at least in part, be explained by the reduction in action potential amplitude that provokes a decrease in neuronal excitability. |
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Keywords: | Essential oil Rosewood oil Hypnotic action Aniba rosaeodora Compound action potential |
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