谷氨酰胺对肿瘤病人的影响

谷氨酰胺是肿瘤细胞的主要能源物质,荷瘤后机体谷氨酰胺的合成和利用发生显著变化,给机体带来不利影响。提供外源性的谷氨酰胺有助于维持荷瘤状态下机体的正常结构和功能,并增强某些化疗药物对肿瘤细胞的杀伤作用,减少放疗或化疗的不良反应。而外源性的谷氨酰胺是否刺激肿瘤生长,仍存有争论。

Effects of glutumine on the patient with tumor (Review)

Glutamine is the key fuel for tumor cell. As comparing that in the healthy body. the synthesis and utilization of glutamine change a lot in the tumor-bearing body, which results in detrimental change in the body's architecture. The provision of exogenous glutamine not only supports to maintain the normal structure and fuction of the tumor-bearing body, but also facilitates chemotherapy while reducing the toxic side effects of chemotherapy or radiotherapy. However.it is still a contravertial question that whether the exogenous glutamine stimulates tumor's growth or not.