低位直肠癌吻合器保肛术后靶向化疗的临床研究

目的 探讨国产吻合器吻合加靶向化疗在低位直肠癌治疗中的应用.方法 回顾性总结1990年1至2004年12月284例低位直肠癌应用国产吻合器行结直肠吻合,术后靶向化疗的经验.结果 所有患者均行保肛手术,术后2例发生吻台口瘘,发生率为0.8%.吻合口狭窄1例,发生率为0 4%.吻合口出血1例发生率为0.4%.切口感染5例,发生率为2.1%.术后复发率为1.7%(4/236).1、3、5年生存率分别为97.2%,86.9%,65.3%.全组无手术死亡.结论 国产吻合器在低位直肠癌保肛手术中是安全可靠的,可以帮助外科医生完成手法缝合难以完成的低位结直肠吻合术.

The domestic stapling technique for anus-preserving and targeted chemotherapy after operation for low rectal cancer

Objective To evaluate the role of domestic stapling technique in anus-preserving operation and targeted chemotherapy after operation for patients with low rectal carcinoma.Methods The domestic stapling technique was used for anus-preserving in colorectal anastomosis after anterior resection and targeted chemotherapy ,was given after operation in 284 patients with low rectal cancer,from 1990 to 2004. Results All patients were successful in anus-preserving. 2(0.8%) patients had anastomotic fistula,1(0.4%)had anastomotic stencosis,1(0.4%)had anastomotic bleeding,5(2.1%)had wound infection,and 4(1.7%)had anastomotic stenosis.One-,three-and five-year survival rates were 97.2%,86.9%,65.3% respectively.There,was no operative death.Conclusion The domestic stapling technique and tar-geted chemotherapy after operation constitutes a safe alternative treatment for anus-pre- serving in patients with low rectal cancer.