阿伦磷酸钠含量对骨水泥静态机械性能的影响

目的：观察阿伦磷酸钠含量对骨水泥浸提前、浸提4周后静态机械性能的影响，从生物力学角度确定阿伦
磷酸钠的合适加入量。方法：在50 g Cemex®XL骨水泥粉末中分别加入0，10，50，100，500，1 000 mg阿伦磷酸钠制
备标本(依次命名为G0~G5组)。万用测试仪测定各组骨水泥浸提前、浸提4周后的压缩强度、弯曲强度(模量)；扫描
电子显微镜观察部分标本断面，显微CT测定标本孔隙率。结果：各组骨水泥浸提前、浸提4周后及浸提前后压缩
强度差异无统计学意义(P>0.05)；与G0组比较，浸提前或浸提4周后G1~G4组弯曲强度或弯曲模量均无明显改变
(P>0.05)，而与G5组弯曲强度有明显差异(P<0.05)；G5组浸提4周后弯曲模量与G0组差异有统计学意义(P<0.05)；
各组浸提前后弯曲强度差异均无统计学意义(P>0.05)；各组浸提前弯曲模量差异无统计学意义(P>0.05)，浸提前后弯
曲模量差异有统计学意义(P<0.05)。结论：50 g骨水泥粉末中阿伦磷酸钠加入量不超过500 mg对浸提前，浸提4周后的
静态机械性能无明显影响。

Effect of alendronate amount on the static mechanical properties of bone cement

Objective: To determine the effect of alendronate amount on the static mechanical properties
of bone cement before elution and 4 weeks after elution, and determine suitable amount of
alendronate in cement from the perspective of biomechanics.
Methods: Samples of compression strength and bending strength (modulus) were prepared with bone
cement adding 0, 10, 50, 100, 500 and 1000 mg alendronate in 50 g Cemex®XL bone cement powders
respectively (named as G0–G5 groups). The compression strength, bending strength, and bending
modulus of bone cement were examinated by INSTRON 8032 tester before the elution and 4 weeks
after the elution. Some broken samples of 4-point bending test were examinated by scanning electronic
microscopy (SEM), and some other samples of bending strength (modulus) tests by micro-CT.
Results: No significant difference was found in the compression strength before the elution, 4 weeks after elution in the 6 groups, and before and after the elution in the respective groups
(P>0.05). Compared with G0 group, G1–G4 groups had no obvious difference in the bending
strength before the elution and 4 weeks after the elution (P>0.05), while G5 group had difference
(P<0.05). There was no significant difference in the bending strength before and after the elution in
the respective groups (P>0.05). Taken G0 group as the control group, G1–G4 groups had no visible
effects on the bending modulus 4 weeks after the elution (P>0.05), while G5 group decreased it
significantly (P<0.05). Bending modulus before the elution in the 6 groups didn’t show obvious
difference (P>0.05), while bending modulus before and after the elution in the respective groups
displayed a marked difference (P<0.05).
Conclusion: Less than 500 mg alendronate added in Cemex®XL 50 g bone cement powder does
not decrease the compressive strength, flexural strength and flexural modulus before the elution and
4 weeks after the elution.