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| 错配修复基因和结肠癌的关系 | |
| 引用本文： | 马俊丽,曾珊. 错配修复基因和结肠癌的关系[J]. 中南大学学报(医学版), 2014, 39(2): 190-194. DOI: 10.11817/j.issn.1672-7347.2014.02.014 |
| 作者姓名： | 马俊丽 曾珊 |
| 作者单位： | 中南大学湘雅医院肿瘤科,长沙 410008 |
| 基金项目： | 国家自然科学基金(项目编号：30770971,30800518,81102046,81070362,81172470)湖南省自然科学基金(11JJ2049,12JJ3118).,This,work,was,supported,by,the,National,Natural,Science,Foundation(项目编号：30770971,30800518,81102046,81070362,81172470)the,Natural,Science,Fund,of,Hunan,Province,P.R.China(项目编号：11JJ2049,12JJ3118) |
| 摘 要： | 错配修复系统(mismatch repair,MMR)是机体DNA修复机制的一种形式,主要纠正碱基错配,防止基因 突变和维持基因组稳定性。miRNA介导的MMR表达异常和结肠癌的发生发展关系密切,MMR表达缺陷(dMMR)的结 肠癌有独特的临床特征,可以作为结肠癌的潜在预后及疗效预测因子。研究MMR与结肠癌的发生、MMR与miRNA的 相互关系及MMR疗效预测等具有非常重要的意义。 |
| 关 键 词： | 错配修复基因 微卫星不稳定性 miRNA 结肠癌 |
Relation between mismatch repair genes and colon cancer |
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| MA Junli,ZENG Shan. Relation between mismatch repair genes and colon cancer[J]. Journal of Central South University. Medical sciences, 2014, 39(2): 190-194. DOI: 10.11817/j.issn.1672-7347.2014.02.014 | |
| Authors: | MA Junli ZENG Shan |
| Affiliation: | Department of Oncology, Xiangya Hospital, Center South University, Changsha 410008, China |
| Abstract: | Mismatch repair (MMR) system is one form of DNA repair mechanisms, which plays an important role in rectifying the mismatch of base pairs, reducing gene mutations and keeping genome stability. Abnormal expression of MMR regulated by miRNA is closely related to the development of colon cancer. Functional defects of MMR (dMMR) with particular clinical characteristics can be used as a potential prognostic and predictive biomarker. This article reviews the relation between MMR system, miRNA and colon cancer. |
| Keywords: | mismatch repair gene microsatellite instability miRNA colon cancer |
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