| Expression of insulin－like growth factor 1 and insulin－like growth factor 1 receptor and its intervention by interleukin－lO in experimental hepatic fibrosis |
| |
| 引用本文： | Wang XZ,Chen ZX,Zhang LJ,Chen YX,Li D,Chen FL,Huang YH. Expression of insulin－like growth factor 1 and insulin－like growth factor 1 receptor and its intervention by interleukin－lO in experimental hepatic fibrosis[J]. World journal of gastroenterology : WJG, 2003, 9(6): 1287-1291 |
| |
| 作者姓名： | Wang XZ Chen ZX Zhang LJ Chen YX Li D Chen FL Huang YH |
| |
| 作者单位： | Department of Gastroenterology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian Province, China |
| |
| 摘 要： |
|
| 关 键 词： | 肝纤维化 胰岛素样生长因子－1 受体 白细胞介素－10 |
Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis |
| |
| Wang Xiao-Zhong,Chen Zhi-Xin,Zhang Li-Juan,Chen Yun-Xin,Li Dan,Chen Feng-Lin,Huang Yue-Hong. Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis[J]. World journal of gastroenterology : WJG, 2003, 9(6): 1287-1291 |
| |
| Authors: | Wang Xiao-Zhong Chen Zhi-Xin Zhang Li-Juan Chen Yun-Xin Li Dan Chen Feng-Lin Huang Yue-Hong |
| |
| Affiliation: | Department of Gastroenterology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian Province, China |
| |
| Abstract: | AIM: To study the expression of IGF-1 and IGF-1R and its intervention by interleukin-10 in the course of experimental hepatic fibrosis. METHODS: Hepatic fibrosis was induced in rats by carbon tetrachloride intoxication and liver specimens were taken from the rats administered CCl4 with or without IL-10 treatment and the animals of the control group. Immunoreactivities for insulin-like growth factor-1 (IGF-1) and IGF-1 receptor(IGF-1R) were demonstrated by immunohistochemistry, and their intensities were evaluated in different animal groups. RESULTS: The positive levels for IGF-1 and IGF-1R were increased with the development of hepatic fibrosis, with the positive signals localized in cytoplasm and/or at the plasmic membrane of hepatocytes. The positive signals of IGF-1 and IGF-1R were observed more frequently (P<0.01) in the CCl4-treated group (92.0 % and 90.0 %) compared to those in the control group. The positive signals decreased significantly (P<0.05) in IL-10-treated group. The responses in IGF-1 and IGF-1R expression correlated with the time of IL-10 treatment. CONCLUSION: The expression of IGF-1 and IGF-1R immunoreactivities in liver tissue seems to be up-regulated during development of hepatic fibrosis induced by CCl(4), and exogenic IL-10 inhibits the responses. |
| |
| Keywords: | |
| 本文献已被 维普 万方数据 PubMed 等数据库收录！ |
|
