复B阿托品溶液中B族维生素及阿托品含量测定方法研究

目的：建立复B阿托品溶液的含量测定方法。方法：采用高效液相色谱（HPLC）法分别对处方中维生素B1、维生素B2、维生素B6、烟酰胺及硫酸阿托品进行定量分析。结果：维生素B1、维生素B2、维生素B6、烟酰胺及硫酸阿托品分别在其最大吸收波长下达到基线分离，线性范围较宽且线性关系良好。结论：所建立的方法简便可行，重现性好，可用于复Ｂ阿托品溶液的质量控制。

Content Determination of Various Components in Vitamin B Complex Atropine Solution

Objective: To establish a method for determination of Vitamin B Complex Atropine Solution. Methods: The major components named vitamin B1, vitamin B2, vitamin B6, nicotinamide and atropine sulfate in Vitamin B Complex Atropine Solution were determined by HPLC-DAD. Results: The results showed that the major components were well separated and the linear relationships were good within wide ranges by HPLC. Conclusion: The method is convenient, accurate and could be readily utilized as a quality control method for the Vitamin B Complex Atropine Solution.