Cerebellar activation and lateralization during verbal and visuospatial tasks as revealed by fMRI |
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| Authors: | Jeong-Han Yi Su-Jeong Lee Jae-Woong Yang Jin-Seung Choi Hyung-Sik Kim Gye-Rae Tack Soon-Cheol Chung Byung-Chan Min Se-Jin Park Jae-Hoon Jun |
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| Affiliation: | Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea,Department of Industrial & Management Engineering Hanbat National University Daejeon, South Korea,Division of Technology Services, National Center for Standard Reference Data, Korea Research Institute of Standards and Science, Daejeon, South Korea,Department of Biomedical Engineering, Research Institute of Biomedical Engineering,College of Biomedical & Health Science, Konkuk University, Chungju, South Korea |
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| Abstract: | BACKGROUND: Many studies concerning cerebral activation and lateralization of cognitive functions are being conducted. Cerebellar function has been much researched with reference to high-level cognitive processing, but has been barely researched in systematization and diversification. In particular, cerebellar lateralization has never been researched, in comparison to cerebral lateralization for which reliable results have been reported.OBJECTIVE: This study ascertains cerebellar activation and its lateralization in relation to verbal and visuospatial tasks, using functional magnetic resonance imaging (fMRI).DESIGN, TIME, AND SETTING: A block design for functional Magnetic Resonance Imaging (fMRI) observation. This study was performed at the fMRI Laboratory, Brain Science Research Center, Korea Advanced Institute of Science and Technology from May 2006 to September 2008.PARTICIPANTS: Sixteen healthy male college students (23.3 ± 0.5 years) and another sixteen healthy male college students (21.5 ± 2.3 years) participated in this fMRI study of verbal and visuospatial tasks, respectively. METHODS: The verbal and visuospatial tasks were presented while functional brain images were acquired using a 3T fMRI system (ISOL Technology, Korea). The verbal analogy testing required the subject to select the word which had the same relationship as one of the given words. The verbal antonym testing required the subject to select the word which had a different meaning among 4 words. The visuospatial tasks involved selecting a shape that corresponded to a given figure using four examples, as well as selecting a development figure of a diagram. MAIN OUTCOME MEASURE: The double subtraction method was used to analyze the differences of the cerebellar activation between the two cognition tasks. The numbers of activated voxels were calculated in bilateral cerebellums for the two tasks. The lateralization index of the cerebellum was calculated for each task.RESULTS: The bilateral hemisphere lobule VI and IX, the right hemisphere lobule VIII, the bilateral hemisphere lobule crus I, and the vermis lobule IV, V and VI are closely related to verbal tasks in comparison to visuospatial tasks. Conversely, the bilateral hemisphere lobule IV and V, and the right hemisphere lobule VI were closely related to visuospatial tasks compared to verbal tasks. There was no great difference between the bilateral cerebellums in the numbers of activated voxels for the tasks and cerebellar lateralization was not observed.CONCLUSION: In the case of the cerebellum, the activation region was different between the verbal and visuospatial tasks, but lateralization was not different. |
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| Keywords: | cerebellum lateralization fMRI verbal and visuospatial tasks |
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