神经干细胞增殖分化的JAK/STAT与Notch信号通路串话机制

JAK／STAT通路参与细胞的增殖、分化和凋亡等过程，近年来的研究显示，其在胚胎发育、成年个体脑肿瘤、脑缺血及损伤后脑内神经干细胞增殖过程中发挥重要作用。Notch介导的信号通路广泛存在于所有已知动物细胞中，是调控神经干细胞增殖、分化的经典信号通路。两条通路形成一个整体网络调控着神经干细胞增殖分化，本文综述Notch通路与JAIL／STAT通路在神经干细胞增殖过程中各组分的相互联系，旨在从网络药理学角度为脑缺血后神经保护及调控神经干细胞增殖药物的开发提供基础理论支持。

Mechanism of JAK/STAT signal pathway and Notch signaling crosstalking in the proliferation and differentiation of neural stem cells

JAK/STAT is a pleiotropic signal transduction pathway with functions of regulating proliferation, differentiation and apoptosis in the cell. Recent research has shown that it plays an important role in embryonic development, brain tumors, cerebral is- chemia and neural stem cell（NSC） proliferation process after brain injuries. Notch signaling pathway exists in all known animal cells, and it is a classic signaling pathway in the regulation of NSC proliferation and differentiation. Under the guidance of the network phar- macology, this article casts light on the crosstalk between JAK/STAT and Notch signal pathway in NSC proliferation, with the aim to provide basic theoretical supports in the research of drugs with the effectiveness of neuroprotection and NSC regulation after cerebral is- chemia.