E-cad在肺癌的表达及意义

目的研究E-cad在肺癌的表达及意义,探讨其与肺癌的组织类型、病理分级及淋巴结转移的关系。方法应用免疫组化S-P法检测E-cad在104例肺癌的表达,其中鳞癌46例、腺癌33例、小细胞癌10例、其它类型癌15例。结果E-cad在104例肺癌的阳性表达为鳞癌21例(45.7%),腺癌14例(42.4%),小细胞癌5例(50%),其它类型癌为7例(46.7%)。结果显示E-cad的阳性表达与肺癌组织类型无相关性(P>0.05);淋巴结转移阳性表达(32.1%),无淋巴结转移阳性表达(64.6%),二者表达有显著相关性(P<0.05);病理分级(腺癌、鳞癌)Ⅰ级阳性表达(55.6%),Ⅱ级阳性表达(40%),Ⅲ级阳性表达(29.6%),结果显示也有明显相关性(P<0.05)。结论肺癌组织中E-cad的阳性表达与肺癌淋巴结转移及分化程度有关。检测E-cad的表达可作为判断肺癌预后的重要指标。

Expression and significance of E-cadherin in lung carcinoma

Objective To study the expression and significance of E-cadherin in lung carcinoma. Methods The expression of E-cadherin was studied by immunohistochemical technique (S-P method) in 104 cases of lung carcinoma (15 cases of squamous cell carcinomas,33 cases of adenocarcinomas,10 cases of small- cell carcinomas,15 cases of other carcinomas).Results Positive expression of E-cadherin was detected in 21 of 46 cases of squamous cell carcinomas (45.7%),in 14 of 33 cases of adenocarcinomas (42.4%),in 5 of 10 cases of small carcinomas (50%) and in 7 of 15 cases of other carcinomas (46.7%).E-cadherin exprression rate of well differentiated carcinoma and moderately differentiated carcinoma was significant higher than that of poorly differentiated carcinoma (P<0.05).The expression rate of E-cadherin in lung carcinoma without lymph node metastasis was significant highetr than those with lympy node metastasis(P<0.05).Conclusion The expression of E-cadherin can be regarded as valuable indicators for evaluating biological behavior and the prognosis of lung carcinoma.