| 1—（2—吡啶基）哌嗪的合成 |
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| 引用本文： | 孙楠,孙雅泉,杨忠愚,胡惟孝. 1—（2—吡啶基）哌嗪的合成[J]. 中国医药工业杂志, 2001, 32(3): 133-134 |
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| 作者姓名： | 孙楠 孙雅泉 杨忠愚 胡惟孝 |
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| 作者单位： | 浙江工业大学化工学院, |
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| 摘 要： | 用工业品2－氨基吡啶在Br2-HBr体系中重氮化，制得2－溴吡啶，收率73．5％；2－溴吡啶与工业无水哌秦直接反应,制得1－（2－吡啶基）哌嗪，收率60％。
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| 关 键 词： | 2－溴吡啶 1－（2－吡啶基）哌嗪 合成 |
| 文章编号： | 1001-8255(2001)03-0133-02 |
| 修稿时间： | 1999-04-05 |
Synthesis of 1- (2-Pyridyl) piperazine |
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| SUN Nan,SUN Ya Quan,YANG Zhong Yu,HU Wei Xiao. Synthesis of 1- (2-Pyridyl) piperazine[J]. , 2001, 32(3): 133-134 |
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| Authors: | SUN Nan SUN Ya Quan YANG Zhong Yu HU Wei Xiao |
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| Abstract: | The pharmaceutical intermediate 1 (2 pyridyl)piperazine was synthesized by two steps.Fristly,the 2 bromopyridine was prepared by diazotization of 2 aminopyridine in Br 2 HBr solution with 73.5% yield. Secondly,2 bromopyridine reacted with anhydrous piperazine in n pentanol to prepare the title compound with 60% yield. |
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| Keywords: | bromopyridine 1 (2 pyridyl)piperazine synthesis |
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