| 中药肝力克对实验性大鼠肝纤维化的影响 |
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| 引用本文： | 严茂祥,陈芝芸,项柏康.中药肝力克对实验性大鼠肝纤维化的影响[J].浙江中医药大学学报,2003,27(5):55-57. |
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| 作者姓名： | 严茂祥 陈芝芸 项柏康 |
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| 作者单位： | 浙江中医学院附属医院,杭州,310006 |
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| 基金项目： | 浙江省教育厅资助项目(NO.19990360),浙江省中管理局资助项目(NO.2000Y03) |
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| 摘 要： | 目的：观察中药肝力克对实验性肝纤维化大鼠肝组织炎症活动度和肝纤维化的影响。方法：大鼠随机分成正常对照组和遣模组。造模组大鼠予40％CCl4皮下注射。造模结束后，将造模组大鼠随机分为肝纤维化模型组，肝力克大、中、小剂量组及秋水仙碱组，并给予不同剂量的药物灌胃治疗，实验结束后处死大鼠，取肝组织常规HE染色，观察大鼠肝组织炎症活动度和肝纤维化程度。结果：肝纤维化模型组大鼠肝组织炎症活动度计分及肝纤维化程度计分均较正常对照组明显升高，差异有非常显著性意叉；用肝力克各剂量及秋水仙碱治疗后，大鼠肝组织炎症活动度及肝纤维化程度均明显降低，与肝纤维化模型组相比，差异有非常显著性和显著性意叉，其中尤以肝力克大剂量组炎症活动度降低最明显。结论：肝力克有明显减轻实验性肝维化大鼠肝组织炎症活动度及改善纤维化程度的作用。
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| 关 键 词： | 肝纤维化 中医药疗法 肝力克 实验研究 大鼠 |
| 修稿时间： | 2003年6月6日 |
Effects of Ganlike on Experimental Liver Fibrosis in rats |
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| Yan Maoxiang,Chen Zhiyun Xiang Baikang Zhejiang provincial Hospital of TCM,Hangzhou.Effects of Ganlike on Experimental Liver Fibrosis in rats[J].Journal of Zhejiang University of Traditional Chinese Medicine,2003,27(5):55-57. |
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| Authors: | Yan Maoxiang Chen Zhiyun Xiang Baikang Zhejiang provincial Hospital of TCM Hangzhou |
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| Abstract: | Objective:To study the treatment effect of Ganlike,a kind of Chinese herbs compound,on rats with experimental liver fibrosis.Methods:168 SD rats were randomly divided into two groups:the normal and the experimental Rats with experimental liver fibrosis wrer induced by CCl 4 After the model being made,rats in the experimental group were divided into the liver fibrotic model,the big,the middle,the small dosage of Ganlike and the colchicine groups All the rats were treated by opposite medicines;at the end of experiment,all the rats were killed The severity of inflammation and fibrosis in all liver tissuses were measured by semiquantitative scoring Results:The severity of inflammation and fibrosis in all liver tissuses were measured by semiquantitative scoring.Results:The severity of inflammation and liver fibrosis scorings in rats of the liver fibrotic model group were obviously higher than those of the normal group;after the rats had been treated by Ganlike and colchicine,the severity of inflammation and liver fibrosis scorings in rats of all the treatment groups became obviously lower than those of the liver fibrotic model group,( P <0 05; P <0 01),and the severity of inflammation scoring in rats of the big dosage of Ganlike group was markedly lowered,which showed very significant meaning;the severity of inflammation scoring in rats of the big dosage of Ganlike group was higher than those of the middle,small dosage of Ganlike groupsand the colchicine group,which showed significant meaning,but the liver fibrosis scoring of the treatment groups showed no significance Conclusion:Ganlike can relieve the severity of inflammation and liver fibrosis in rat liver tissues |
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| Keywords: | Gankike liver fibrosis experimental research |
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