结缔组织病与甲状腺疾病的相关性

目的探讨常见结缔组织病(connective tissue disease,CTD)与甲状腺疾病的相关性。方法以济宁医学院附属医院2009年1月至2013年4月住院并接受甲状腺功能筛查CTD患者为研究对象,以普通人群为对照,比较CTD患者与普通人群甲状腺疾病的患病率,同时比较不同甲状腺疾病在不同CTD中的患病率。结果 CTD患者780例,包括类风湿关节炎438例(56.2%)、系统性红斑狼疮195例(25.0%)、原发性干燥综合征85例(10.9%)、混合结缔组织病44例(5.6%)、系统性硬化症(SSc)18例(2.3%),其中合并甲状腺疾病286例(36.7%),与普通人群比较(8.7%)明显升高(P0.05)。合并甲状腺疾病的CTD患者,发生率依次为混合结缔组织病61.4%、原发性干燥综合征54.1%、系统性红斑狼疮51.3%、系统性硬化症27.8%、类风湿关节炎24.7%;混合结缔组织病、原发性干燥综合征、系统性红斑狼疮发生率与类风湿关节炎比较,差异有统计学意义(P0.05)。CTD患者合并甲状腺疾病构成比依次为甲状腺功能减退29.4%、甲状腺功能亢进6.3%、桥本甲状腺炎18.5%、低T3综合征26.6%、结节性甲状腺肿18.8%、甲状腺肿瘤0.4%。结论 CTD合并甲状腺疾病发生率较高,应重视两种疾病的相互筛查。

Relationship between Connective Tissue Diseases and Thyroid Diseases

Objective To investigate the correlation between connective tissue diseases （CTD） and thyroid diseases（TD）. Methods The study group included CTD patients who had thyroid function tested and were hospitalized in the Affiliated Hospital of Jining Medical College between January 2009 and April 2013. The control group were healthy volunteers. We compared the prevalence of TD between CTD and normal controls and also the prevalence of different TDs in different CTDs. Results There were 780 CTD patients including 438 （56.2%） rheumatoid arthritis （ RA ）, 195 （ 25.0% ） systemic lupus erythematosus （SLE）, 85 （10.9%） primary Sjogren＇ s syndrome （pSS）, 44 （5.6%） mixed connective tissue disease （MCTD）, 18 （2.3%） systemic sclerosis （SSc） 286 CTD patients suffered from thyroid diseases （36.7%）. The prevalence of TDs in CTD patients （36.7%） were higher than that in the normal controls （8.7%） （P 〈 0.05）. The incidence of CTD associated with thyroid disease was 61.4% in MCTD, 54. 1% in pSS, 51.3% in SLE, 27.8% in SSc and 24.7% in RA; there were significant differences in thyroid disease rates among patients with MCTD, pSS, SLE, compared to RA（P〈0. 6.3%, thyroid in patie 05）. The incidence of thyro Hashimoto＇ s thyroiditis in tumor 0.4%. Conclusion nts with CTDs. id disease in CTD was hypothyroidism in 29.4% , hyperthyroidism in 18.5%, low T3 syndrome in 26. 6%, nodular goiter in 18.8%, CTD is often associated with TDs, so screening for TDs should be onein patients with CTDs.