| 氧化乐果对小鼠睾丸细胞DNA的损伤 |
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| 引用本文： | 张波,朱莉萌. 氧化乐果对小鼠睾丸细胞DNA的损伤[J]. 环境与健康杂志, 2005, 22(6): 468-469 |
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| 作者姓名： | 张波 朱莉萌 |
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| 作者单位： | 北京联合大学应用文理学院生物学系,北京,100083;北京联合大学应用文理学院生物学系,北京,100083 |
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| 基金项目： | 北京市教委科技发展项目（KM200411417001） |
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| 摘 要： | 目的 研究有机磷农药氧化乐果对小鼠睾丸细胞DNA的损伤作用.方法 24只昆明小鼠随机分成4组（对照组、1、2、4mg/kg染毒组）,每组6只.经口染毒7 d,用彗星试验技术（SCGE）检测小鼠睾丸细胞DNA的损伤.结果 1、2、4 mg/kg氧化乐果暴露的小鼠睾丸细胞彗星尾长和彗星尾长与头长之比均大于对照组（P＜0.01）,且随氧化乐果染毒剂量的增加,睾丸细胞彗星尾长也增加,具有剂量-效应关系.结论 氧化乐果可引起小鼠睾丸细胞DNA的损伤.
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| 关 键 词： | DNA损伤 农药 氧化乐果 单细胞凝胶电泳 |
| 文章编号： | 1001-5914(2005)06-0468-02 |
| 收稿时间： | 2005-03-28 |
| 修稿时间： | 2005-03-28 |
Effect of Omethoate on DNA in Mice Testicle Cells |
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| ZHANG Bo,ZHU Li-meng. Effect of Omethoate on DNA in Mice Testicle Cells[J]. Journal of Environment and Health, 2005, 22(6): 468-469 |
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| Authors: | ZHANG Bo ZHU Li-meng |
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| Affiliation: | The Biology Department of College of Arts and Sciences of Beijng Union University, Beijing 100083, China |
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| Abstract: | Objective To study the adverse effect of omethoate on DNA in mice testicle cells in vivo.Methods 24 mice were randomly divided to 4 groups:control(no omethoate),1,2 and 4 mg/kg.omethoate was given by gavage one time a day for consecutive 7 days.DNA damage was detected by single cell gel electrophoresiss (SCGE).Results At the concentration of 1,2,4 mg/kg,omethoate induced DNA damage in mice testicle cells in vivo with an obvious dose-effect relationship(r=0.969 5).Conclusion Omethoate may cause DNA damage in mice testicle cells. |
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| Keywords: | DNA damage Pesticide Omethoate Single cell gel electrophoresiss |
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