| 卡因酸耳蜗毒性的电生理学研究 |
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| 引用本文： | 韩仕龙,孔维佳.卡因酸耳蜗毒性的电生理学研究[J].临床耳鼻咽喉头颈外科杂志,1999,13(7):321-322. |
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| 作者姓名： | 韩仕龙 孔维佳 |
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| 作者单位： | 1. 九江医学专科学校附属医院耳鼻咽喉科
2. 同济医科大学附属协和医院耳鼻咽喉科,武汉,430022 |
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| 摘 要： | 目的：观察谷氨酸类受体激动剂卡因酸（ＫＡ）对豚鼠耳蜗的毒性作用。方法：健康杂色豚鼠８只，每只动物经圆膜给予６０ｍＭ ＫＡ１μｌ，于用药前及用药后１２ｈ分别检测听神经复合动作电位（ＣＡＰ），耳蜗微音电位（ＣＭ）和畸变产物耳声发射（ＤＰＯＡＥ）之２ｆ２－ｆ２。结果：用药后ＣＡＰ明显下降或消失（Ｐ〈０．００１），而ＣＭ和ＤＰＯＡＥ无明显变化。结论：ＫＡ对初级听觉传入神经末梢具有选择性毒性作用。
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| 关 键 词： | 红藻氨酸 听神经复合动作电位 耳蜗微音电位 畸变产物耳声发射 豚鼠 |
An electrophysiological study of the kainic acid toxicity on cochleas |
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| Han Shilong,Kong Weijia.An electrophysiological study of the kainic acid toxicity on cochleas[J].Journal of Clinical Otorhinolaryngology,1999,13(7):321-322. |
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| Authors: | Han Shilong Kong Weijia |
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| Institution: | Department of Otorhinolaryngology, Union Hospital, Tongji Medical University, Wuhan 430022. |
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| Abstract: | Objective: The purpose of this study was to investigate the kainic acid (KA) toxicity on cochleas. Method:One microliter KA in the concentration of 60 mM was applied to the round window membrane of guinea pig.The compound action potential (CAP),cochlear microphonic potential (CM) and distortion product otoacoustic emissions (DPOAE) were measured 12 hours after KA was administrated. Result: CAP was suppressed significantly or abolished after the drug administration,however,the CM and DPOAE almost presented no change. Conclusion: The targets of KA toxicity are the primary auditory afferent endings. |
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| Keywords: | Kainic acid Compound action potentialCochlear microphonic potentialDistortion product otoacoustic emissionsGuinea pigs |
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