| 抑癌基因PTEN的表达与胃癌生物学行为及预后的关系 |
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| 引用本文： | 郭强,孙晓霞,徐亮. 抑癌基因PTEN的表达与胃癌生物学行为及预后的关系[J]. 中国误诊学杂志, 2004, 4(11): 1776-1778 |
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| 作者姓名： | 郭强 孙晓霞 徐亮 |
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| 作者单位： | 1. 泸州医学院附属医院普外科,四川,泸州,646000
2. 山东省胜利石油管理局胜北医院 |
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| 基金项目： | 四川省卫生厅资助项目 (编号 :0 0 0 1 1 4 ) |
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| 摘 要： | 目的：评价胃癌组织中抑癌基因PTEN的表达与胃癌生物学行为及预后的关系。方法：对1997～1998年60例胃癌患者的手术标本，以PTEN单抗行免疫组织化学染色(SABC法)。结合临床资料进行分析。结果：胃癌组织中PTEN的阳性表达率为46．7％，PTEN的阳性表达与性别、年龄无关；与肿瘤大小、Borrmann分型、淋巴结转移、肿瘤分期呈负相关；与患者的术后生存时间呈正相关。结论：PTEN的表达与胃癌的生物学行为及患者的预后有密切关系。
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| 关 键 词： | 基因 肿瘤抑制 免疫组织化学 胃肿瘤／遗传学 预后 |
| 文章编号： | 1009-6647(2004)11-1776-03 |
| 修稿时间： | 2004-09-11 |
Microvessel Density (MVD), And Expression Of Vascular Endothelial Growth Factor(VEGF) And PTEN Correlates With Biological Character and Prognosis Of Gastric Cancer |
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| GUO Qiang,SUN Xiao-xia,XU Liang. Microvessel Density (MVD), And Expression Of Vascular Endothelial Growth Factor(VEGF) And PTEN Correlates With Biological Character and Prognosis Of Gastric Cancer[J]. Chinese Journal of Misdiagnostics, 2004, 4(11): 1776-1778 |
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| Authors: | GUO Qiang SUN Xiao-xia XU Liang |
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| Abstract: | Objective:To evaluate the relationship between expression of tumor suppressor gene PTEN and tumor biological character and patient prognosis in gastric cancer.Methods:Sixty surgical specimens of gastric cancer between 1997 and 1998 were selected. PTEN were determined by immunohistochemistry SABC method.Results:In 46.7% gastric cancer PTEN was positive, others negative. There were significant difference and negative correlations between PTEN and tumor size (P<0.01), Borrmann type (P<0.05), lymph node metastasis (P<0.01), tumor stage (P< 0.05) ;but there was positive correlation between PTEN and prognosis (P<0.01).Conclusion:PTEN should correlate with the biological characters of gastric cancer and patient prognosis. |
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| Keywords: | Genes tumor suppressor Stomach neoplasms/genetics Immunohistochemistry Prognosis |
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