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| 引用本文： | 穆亚平,赵方,马洪刚,刘立旻,李娜,王岩,李玢,关丽君,李书琴,韩萍,辛颖. ��ͯ�����������֢��֬��л�쳣������Ϻ�Ԥ���о�[J]. 中国实用儿科杂志, 2011, 26(8): 587 |
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| 作者姓名： | 穆亚平 赵方 马洪刚 刘立旻 李娜 王岩 李玢 关丽君 李书琴 韩萍 辛颖 |
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| 作者单位： | 1.?????ж????????????110032??2. ?й??????????????110001??3. ?й???????????????????????110004 |
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| 摘 要： | 目的探寻肥胖与糖脂代谢异常的相关性及相应靶器官肝脏、心脏损害情况,以早期采取干预措施。方法选择2008年7月至2010年10月沈阳市儿童医院儿保门诊就诊的单纯性肥胖儿童516例为肥胖组,100名体检体重正常儿童为对照组。取空腹静脉血检测空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、谷丙转氨酶(ALT)、空腹胰岛素(FINS)等指标,计算胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能值(HOMA-β);对肥胖儿童行口服糖耐量试验(OGTT)和胰岛素释放试验。对所有入组者均进行肝脏和心脏超声检查。结果肥胖组收缩压、舒张压均高于对照组(P<0.05),肥胖组高血压检出率为12.0%(62/516)。肥胖组FBG、FINS、HOMA-IR及HOMA-β均高于对照组(P<0.05);TC、TG、LDL-C均高于对照组,而HDL-C低于对照组,差异均有统计学意义(P<0.05)。轻、中、重度肥胖组脂肪肝发生率差异有统计学意义(P<0.001),且随肥胖程度加重,脂肪肝发生率明显增加(χ2=12.97,P<0.001)。肥胖组心包外脂肪增厚268例,平均厚度(3.372±0.098)mm,与对照组比较差异有统计...
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| 关 键 词： | ??? ?????? ???? ??л????? ????? ???????? ??????????? |
Research into abnormal glucose and lipid metabolism in early diagnosis and intervention in obese children and adolescents |
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| MU Ya-ping,ZHAO Fang,MA Hong-gang,LIU Li-min,LI Na,WANG Yan,LI Bin,GUAN Li-jun,LI Shu-qin,HAN Ping,XIN Ying.Shenyang Children's Hospital,Shenyang ,China. Research into abnormal glucose and lipid metabolism in early diagnosis and intervention in obese children and adolescents[J]. Chinese Journal of Practical Pediatrics, 2011, 26(8): 587 |
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| Authors: | MU Ya-ping ZHAO Fang MA Hong-gang LIU Li-min LI Na WANG Yan LI Bin GUAN Li-jun LI Shu-qin HAN Ping XIN Ying.Shenyang Children's Hospital Shenyang China |
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| Affiliation: | Shenyang Children's Hospital??Shenyang 110032??China |
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| Abstract: | Objective To explore the relationship between obesity and glucose and lipid metabolism,and the damage of the related target organs such as liver and heart in order to take early intervention.Methods Totally 516 children with simple obesity made up obesity group,100 normal-weight children as a control group.Detect the fasting plasma glucose(FPG),triglyceride(TG),total cholesterol(TC),alanine aminotransferase(ALT),fasting insulin(FINS) and other projects;calculate the insulin resistance index(HOMA-IR) and ins... |
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| Keywords: | children youth adolescents metabolic syndrome fatty liver left ventricular hypertrophy external pericardial fat thickness |
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