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目的探讨孤独症患儿头围发育情况。方法研究对象为中国医科大学附属盛京医院2009年9月至2011年6月确诊的孤独症患儿(孤独症组)156例,其中≤3岁74例,>3岁82例。同时选择健康儿童141名作为正常对照组,其中≤3岁58名,>3岁83名。分别测量两组头围并进行组间比较。结果孤独症组≤3岁患儿头围平均值与大头所占比例均大于正常对照组,两组差异有统计学意义(P<0.05)。孤独症组>3岁患儿头围平均值与大头所占比例与健康儿童基本相似,两组差异无统计学意义(P>0.05)。在除外大头患儿后,两组头围平均值比较差异无统计学意义(P>0.05)。结论孤独症患儿生后早期头围偏大,并且常伴大头,头围异常也是患儿重要的临床特征之一。了解孤独症头围发育可为孤独症的发病机制提供参考依据。

Head circumference measurements in children with autism

??Abstract??Objective??To assess the head circumference in children with autism. Methods??One hundred and fifty-six children with autism ??74 children ≤ 3 years and 82 children > 3 years?? respectively?? and 141 well-matched healthy controls??58 children ≤3 years and 83 children> 3 years?? respectively?? were investigated by measuring the head circumference. Results??The autistic children demonstrated significantlyhigher head circumference than the control children in the ≤3 years group ??P < 0.05??.Compared to the healthy controls?? the autistic individuals also manifested more macrocephalus??P < 0.05??. However?? when the children who displayed macrocephalus were excluded?? there was no significant difference in the head circumference between the two groups. Conclusion??Head circumference abnormalities are a common feature of autistic patients and may provide some clues to the pathogenesis of autism.