陈旧性心肌梗死患者甲状腺素水平及临床意义

目的:探讨陈旧性心肌梗死(OMI)患者甲状腺素水平及临床意义。方法:采用放射免疫法测定51例OMI患者及49例正常对照组中三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺素(TSH)。同时检测血中总胆固醇(TC)、甘油三脂(TC),高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)。结果:OMI患者血中T_3、T_4、FT_3明显低于正常对照组(P<0.01～0.05),TC、TG、LDL、VLDL明显高于对照组(P<0.01),HDL则明显低于对照组(P<0.01),OMI患者血脂各指标与甲状腺素各指标间均无明显相关性(P>0.05)。结论:OMI患者甲状腺素降低,可能是OMI的继发性改变,而血脂水平的变化与甲状腺素水平的变化无相关关系。

The Change of Thyroid Hormone Level in Serum in Patients with Old Myocardial Infarction and Its Clinical Significance

Objective:To investigate the change of the thyroid hormone level in serum in patients with old myocardial infarction (OMI) and its clinical significance. Methods: 51 patients with OMI and 49 normal persons (control) were involved in this study.The triiodothyronine(T3) ,thyroxine (T4),free triiodothyronine(FT3) ,free thyroxine (FT4) and thyroid stimulating hormone (TSH) were detected by radioimmunoassay. The Shimadzu CL-7000 automatic biochemical analyzer was used to determine the total cholesterol (TC) , total triglyceride ( TG), High-density lipoprotein ( HDL), low-density lipoprotein ( LDL) and very low-density lipoprotein (VLDL)in serum.Results:The concentration of T3,T4,FT3 in patients with OMI was remarkably lower compared with that in normal control group. (P < 0.05 -0.01), and the level of TC,TG,LDL, VLDL in patients with OMI was apparently higher while the HDL was signficantly lower. There was no correlation between the lipids and the thyroid hormones in patients with OMI. Conclusion: The concentration of the thyroid hormones in patients with IMI is decreased and this may be a secondary change from OMI. The change of the lipids isn' t correlative to the alteration of the thyroid hormones.