碱性成纤维细胞生长因子复合制剂局部治疗复发性阿弗他溃疡的临床研究

目的：观察bFGF复合制剂局部治疗复发性阿弗他溃疡的近期疗效。方法：bFGF组60例应用bFGF与适量替硝唑、地卡因配伍成复合制剂喷涂于溃疡面；常规治疗组40例应用锡类散、思密达交替涂敷于溃疡面，均每日3次，疗程5d。结果：bFGF组溃疡大小、疼痛及充血3项指标改善值均明显优于对照组（P＜0．001），临床疗效较常规治疗组显（P＜0．05）。无明显不良反应。结论：该复合制剂局部治疗复发性阿弗他溃疡安全、有效。

Clinical study of compound bFGF preparations on patients with recurrent aphthous ulcer

AIM: To observe the recent curative effect of basic fibroblast growth factor(bFGF) to patients with recurrent aphthous ulcer(RAU). METHODS: 60 patients with RAU were treated by locally spraying compound bFGF preparations composing of calculated quantity of bFGF, tinidazole and dicaine on the surface of ulcerations,?other?40?patients?were?treated?by?alternatively smearing Xi Leisan and Smecta on the surface of ulcerations as routine treatment group, tid, for 5 d. RESULTS: The improvement of three indexes including the size, the degree of ache and hyperemia of the ulcerations are greater in compound bFGF treatment group than those in routine treatment group (P<0.001),and the effective rate was also higher in bFGF treatment group ( 86.67 %) than those in ( 65.00 %) routine treatment group (P< 0.05 ). No significant side effect was observed during the treatment with compound bFGF. CONCLUSION: The compound bFGF preparations used in this study is effective and safe for the treatment of RAU.