| 血浆S100B蛋白在缺氧缺血性脑病新生儿的诊断评估 |
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| 引用本文： | 姜东林,孙钧铭,李成万,赵磊,华海应,蔡良良.血浆S100B蛋白在缺氧缺血性脑病新生儿的诊断评估[J].中国实验诊断学,2010,14(3). |
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| 作者姓名： | 姜东林 孙钧铭 李成万 赵磊 华海应 蔡良良 |
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| 作者单位： | 1. 南通大学第三附属医院,中心实验室,江苏,无锡214041
2. 南通大学第三附属医院,儿科,江苏,无锡214041 |
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| 摘 要： | 目的 探讨血浆S100B蛋白对缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)新生儿脑损伤的临床意义.方法 选择54例临床诊断为HIE的新生儿在出生12 h时抽血检测S100B、神经元特异性烯醇化酶(neuron specific enolase,NSE)及脑型肌酸激酶同功酶(creatine kinaes BB isozyme,CK-BB),与47例非HIE的窒息新生儿和22例健康新生儿进行对照比较.评价敏感性和特异性,绘制ROC曲线,计算ROC曲线下面积.结果 出生12 h时HIE患儿血浆S100B、NSE和CK-BB阳性率显著高于窒息组和对照组(均P<0.01),S100B对HIE的敏感性为88.89%,特异性为82.61%,之和高于NSE及CK-BB.S100B的ROC曲线下面积最大(面积:0.950;95%可信区间0.918-0.983),临床诊断效能高于NSE及CK-BB.结论 HIE患儿出生12 h时血浆S100B、NSE和CK-BB均能预示HIE患儿的脑部损伤,S100B阳性率最高,三指标联合检测,有助于HIE的早期诊断和病情判断.
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| 关 键 词： | 缺氧缺血性脑病 S100B蛋白 神经元特异性烯醇化酶 脑型肌酸激酶同功酶 |
Diagnostic value of plasma S100B protein in neonates with hypoxic ischemic encephalopathy |
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| JIANG Dong-lin,SUN Jun-ming,LI Cheng-wan,et al..Diagnostic value of plasma S100B protein in neonates with hypoxic ischemic encephalopathy[J].Chinese Journal of Laboratory Diagnosis,2010,14(3). |
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| Authors: | JIANG Dong-lin SUN Jun-ming LI Cheng-wan |
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| Institution: | JIANG Dong-lin1,SUN Jun-ming1,LI Cheng-wan2,et al.(1.Department of Clinical Laboratory,2.Pediatrics,The Third Affiliated Hospital of Nantong University,Wuxi 214041,China) |
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| Abstract: | Objective To discuss the Diagnostic value of plasma S100B protein in neonates with hypoxic ischemic encephalopathy(HIE).Methods Blood testing S100B,NSE and CK-BB on 54 neonates with clinical diagnosis of HIE at the point of 12 hours after birth,then comparing with 47 asphyxial neonates without HIE and 22 healthy neonates,calculating the sensitivity and specificity of detection,protracting ROC curve and calculating the area below the ROC curve.Results The positive rates of S100B,NSE and CK-BB in neonates wit... |
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| Keywords: | hypoxic ischemic encephalopathy S100B protein neuron specific enolase creatine kinaes BB isozyme |
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