Isolation and structural elucidation of new 18-membered macrolide antibiotics, viranamycins A and B. |
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| Authors: | Y Hayakawa K Takaku K Furihata K Nagai H Seto |
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| Affiliation: | Institute of Applied Microbiology, University of Tokyo, Japan. |
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| Abstract: | Two cytotoxic antibiotics, designated viranamycins A and B, were isolated from the culture broth of Streptomyces sp. CH41. Their structures were elucidated as new 18-membered macrolides related to virustomycin A and concanamycin A from NMR spectral analysis. Viranamycins A and B inhibited the growth of P388 mouse leukemia and KB human squamous-cell-carcinoma cells. |
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