四种药物对兔动脉粥样硬化消退治疗的作用

目的 :探讨辛伐他汀、普罗布考、卡托普利和中药对动脉粥样硬化消退作用。　　方法 :55只兔饲养高胆固醇饲料 ,12周末将 40只兔随机分为自然消退组、辛伐他汀组、普罗布考组、卡托普利组和中药组 ,每组 8只 ;于实验开始、 12周末、 2 4周末测量腹主动脉内中膜厚度和内中膜校正的声学密度值 (% )。对比超声测量的内中膜厚度与病理测值。　　结果 :病理测量的腹主动脉内中膜厚度与超声测值差异无统计学意义 (P >0 0 5) ;4个药物治疗组内中膜厚度均显著低于自然消退组 (P均 <0 0 5) ,服药后内中膜厚度依次为辛伐他汀组 <普罗布考组 <中药组 <卡托普利组 <自然消退组。消退治疗后内中膜校正回声强度 (% )均显著增高 (P <0 0 5) ,依次为普罗布考组 >辛伐他汀组 >中药组或卡托普利组。　　结论 :辛伐他汀、普罗布考、卡托普利和中药均有不同程度消退实验兔动脉粥样硬化的作用 ,其中以辛伐他汀效果最佳。高频超声技术可作为定性和定量随访动脉粥样硬化动态变化的可靠方法

Effects of Simvastatin, Probucol, Captopril and Chinese Medicine on Regression of Rabbit Atherosclerosis

Objective: To compare the effects of simvastatin, probucol, captopril and C hinese medicine on the regression of rabbit atherosclerosis (AS) plaque. Methods: Fifty five male new zealand rabbits were fee d with a diet containing 1% cholesterol for 12 weeks.Then fourty rabbits with ath erosclero sis were divided randomly into normal gr oup, regression control group(RC), simvastatin group, probuc ol group, captopril plus Chinese medicine group. The intima media thickness (IMT) and corrected ac oustic densitometry value (AIIc) of abdominal aorta were mea sured with high freq uency ultrasound at beginning, and at 12 and 24 weeks of the experiment. Abd ominal aorta was also examined pathologically at 24 weeks of the experiment. Results: IMT of AS model group was thicker than that of normal group. The IMTs of 4 drug treated groups were thinner than regression control group (p<0 05).At 24 weeks, after drug adminstration IMTs of 5 groups were decreased in the following order: regression control group>captopril group>Chinese medicine group>probucol group>simvastatin group. The AIIc% in 4 drug treated grou ps were significantly higher than AS model group (p<0 05). Conclusions: Simvastatin, probucol, captopril and Chinese medicine can ind u ce regression of atherosclerosis (AS) in the rabbit model, a nd simvastatin has t he best effect. High frequency ultrasound imaging technique provides a reliable method in monitoring the atherosclerosis progression or regression.