| 舒郁胶囊中麻黄碱的鉴别与含量测定研究 |
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| 引用本文： | 白林,任韡,陈利平. 舒郁胶囊中麻黄碱的鉴别与含量测定研究[J]. 中国药物应用与监测, 2011, 8(4): 211-213 |
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| 作者姓名： | 白林 任韡 陈利平 |
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| 作者单位： | 1. 解放军总医院药品保障中心药检室,北京,100853
2. 解放军总医院中医科,北京,100853 |
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| 基金项目： | 解放军总医院新药研发基金课题 |
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| 摘 要： | 目的:建立舒郁胶囊中麻黄碱的鉴别和含量测定方法.方法:采用TLC法和HPLC法对舒郁胶囊中的麻黄碱进行定性鉴别和含量测定.色谱条件:色谱柱为Diamonsil C<,18>柱(250 mm×4.6 mm,5 μm),流动相为乙腈-0.02 mol·L<'-1>磷酸二氢钾-磷酸(50:950:1),流速1.0 mL·mi...
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| 关 键 词： | 舒郁胶囊 盐酸麻黄碱 薄层色谱法 高效液相色谱法 |
Study on the identification and content determination of ephedrine in Shuyu capsule |
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| BAI Lin,REN Wei,CHEN Li-ping. Study on the identification and content determination of ephedrine in Shuyu capsule[J]. , 2011, 8(4): 211-213 |
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| Authors: | BAI Lin REN Wei CHEN Li-ping |
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| Affiliation: | BAI Lin1,REN Wei1,CHEN Li-ping2(1.Department of Drug Analysis,Pharmaceutical Care of PLA General Hospital,Beijing 100853,China,2.Department of Traditional Chinese Medicine,PLA General Hospital,China) |
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| Abstract: | Objective： To establish the method for identification and determination of ephedrine in Shuyu capsule. Methods： Ephedrine in Shuyu capsule was identified by TLC, and the content was determined by HPLC. A Diamonsil C18 column （250 mm × 4.6 mm, 5 μm） was used with a mobile phase consisting of acetonitrile-0.02 mol.Lt potassium dihydrogen phosphate-phosphoric acid （50 ： 950 ： 1） at a flow rate of 1.0 mL.min~, the detection wavelength was 207 nm and the column temperature was 40 ℃. The injection volume was 10μL. Results： The characteristic spot of ephedrine was identified by TLC in Shuyu capsule. The average content of ephedrine in Shuyu capsule was 1.133 2 mg·g^-1; the calibration curve of ephedrine had a good linear relationship at the range of 5.0 μg·mL^-1 to 100.0 μg·mL^-1 （r = 0. 999 96）, and the average recovery was 98.96% （RSD = 0.23%）. Conclusion： This method is simple and repeatable. It can be used for identification and content determination of ephedrine in Shuyu capsule. |
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| Keywords: | Shuyu capsule Ephedrine hydrochloride TLC HPLC |
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