| 壳寡糖促进小鼠坐骨神经再生的实验研究 |
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| 引用本文： | 蒋茂荣,诸葛晓旻,丁斐. 壳寡糖促进小鼠坐骨神经再生的实验研究[J]. 苏州大学学报(自然科学版), 2010, 30(1): 4-6,37,F0002 |
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| 作者姓名： | 蒋茂荣 诸葛晓旻 丁斐 |
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| 作者单位： | 南通大学江苏省神经再生重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(30670667) |
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| 摘 要： | 目的观察壳寡糖（COS）对小鼠损伤坐骨神经的修复作用。方法ICR小鼠50只,行坐骨神经夹伤术,随机分成5组,分别为COS高、中、低剂量组（实验组）,弥可保组（阳性对照组）,生理盐水组（空白对照组）,每组10只,术后每日腹腔注射给药。采用小鼠坐骨神经功能指数（SFI）、组织形态学及电镜检查,观察COS对损伤坐骨神经的影响。结果与空白对照组相比,COS可显著改善小鼠的坐骨神经功能（P〈0.01）。超微结构观察表明,实验组有髓神经纤维的髓鞘形态、厚度、成熟度均优于空白对照组（P〈0.01）,而变性纤维的数目少于空白对照组。结论COS能促进小鼠坐骨神经损伤后的修复及其功能的恢复。
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| 关 键 词： | 壳寡糖 坐骨神经损伤 神经再生 |
Experimental Study of the Repair Effect of Chitooligosaccharide on the Crushed Sciatic Nerve of Mouse |
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| JIANG Mao-rong,ZHUGE Xiao-ming,DING Fei. Experimental Study of the Repair Effect of Chitooligosaccharide on the Crushed Sciatic Nerve of Mouse[J]. Suzhou University Journal of Medical Science, 2010, 30(1): 4-6,37,F0002 |
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| Authors: | JIANG Mao-rong ZHUGE Xiao-ming DING Fei |
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| Affiliation: | JIANG Mao-rong,ZHUGE Xiao-ming,DING Fei(Jiangsu Key Laboratory of Neuroregeneration of Nantong University,Jiangsu Nantong 226001,China) |
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| Abstract: | Objective To investigate the repair effect of chitooligosaccharide(COS)on the crushed sciatic nerve of mouse.Methods Fifty ICR mice,half female and male,were randomly divided into five groups:the high dose COS group,medium dose COS group,low dose COS group,mecobalamine(positive control)group and normal saline(blank control)group.These mice after sciatic nerve crushing were received COS,mecobalamine or normal saline by intraperitoneal injection every day.The effect of COS on the crushed sciatic nerve was obs... |
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| Keywords: | chitooligosaccharide sciatic nerve injury nerve regeneration |
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