Impaired long‐term potentiation–like cortical plasticity in presymptomatic genetic frontotemporal dementia |
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| Authors: | Alberto Benussi MD Maura Cosseddu MSc Ilaria Filareto MD Valentina Dell'Era MD Silvana Archetti MD Maria Sofia Cotelli MD Anna Micheli MD Alessandro Padovani MD PhD Barbara Borroni MD |
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| Affiliation: | 1. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy;2. III Laboratory of Analysis, Spedali Civili Hospital, Brescia, Italy;3. Neurology Unit, Valle Camonica Hospital, Brescia, Italy;4. Casa di Cura San Francesco, Bergamo, Italy |
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| Abstract: | Neurophysiological biomarkers were assessed using a transcranial magnetic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with a pathogenic mutation for frontotemporal dementia (FTD). Intracortical facilitation and long‐term potentiation–like plasticity were impaired in presymptomatic carriers, compared to healthy controls, more than 15 years before expected symptom onset. In symptomatic carriers, a decrease in short‐interval intracortical inhibition, compared to presymptomatic carriers, was found. In conclusion, these biomarkers could provide the footprints of specific physiopathological processes in the development of this disease and possibly support the diagnosis of autosomal‐dominant FTD. Ann Neurol 2016;80:472–476 |
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