Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp |
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| Authors: | Buchanan Malcolm S Carroll Anthony R Addepalli Rama Avery Vicky M Hooper John N A Quinn Ronald J |
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| Affiliation: | Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia. |
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| Abstract: | The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy. |
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