癌基因c-erbB-2、组织蛋白酶D在胃癌中的表达及其意义

目的 探讨癌基因c-erbB-2、组织蛋白酶D（Cath-D)在胃癌中的表达及其与胃癌发展的关系。方法 应用免疫组织化学方法检测102例胃癌组织的c-erbB-2、Cath-d蛋白表达，分析其与胃癌生物学行为之间的关系。结果 c-erbB-2阳性率38.2%，Cath-D阳性率81.4%。c-erbB-2阳性者Cath-D的阳性率明显高于c-erbB-2阴性者，c-erbB-2和Cath-D表达与胃癌浸润深度、淋巴结转移密切相关，而与组织学分型无关。Cath-D表达还与肿瘤的生长方式及脉管内癌栓有关；c-erbB-2和Cath-D表达阳性的胃癌患者5年生存率较表达阴性者低。结论 c-erbB-2和Cath-D对胃癌的生长、浸润和转移有促进作用，c-erbB-2和Cath-d可作为反映胃癌生物学行为的指标之一。

Relationship of c-erbB-2 and Cath-D expression with biological behaviors in gastric carcinoma

Objective To investigate the relationship between the expression of c erbB 2 and Cath D expression with biological behaviors of gastric carcinoma (GC) Methods C erbB 2 and Cath D expression in 102 cases of human GC were examined by use of immunohistochemical staining C erbB 2 and Cath D expression were analyzed together with their relation to biological behaviors of GC Results The positivities of c erbB 2 and Cath D expression in GC were 38 2% and 81 4% respectively Cath D was significantly higher in c erbB 2 postitive GC than negative one C erbB 2 and Cath D were positively correlated with depth of invasion and node metastasis But their relationshiop with the histologic types was not significant Cath D was positively correlated with growth pattern and lymphatic and blood vessels cancerous embolus of GC Five year survival rate was significantly lower in c erbB 2 or Cath D positive GC than that in negative GC Conclusions C erbB 2 or Cath D promotes growth, invasion and metastasis of GC Both c erbB 2 and Cath D are predicators for biological behavior of GC.