Autophagy in renal diseases |
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| Authors: | Stéphanie De Rechter Jean-Paul Decuypere Ekaterina Ivanova Lambertus P. van den Heuvel Humbert De Smedt Elena Levtchenko Djalila Mekahli |
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| Affiliation: | 1.Department of Paediatric Nephrology,University Hospitals Leuven,Leuven,Belgium;2.Laboratory of Paediatrics,KU Leuven,Leuven,Belgium;3.Laboratory of Abdominal Transplantation, Department of Microbiology and Immunology Biomedical Sciences Group,KU Leuven,Leuven,Belgium;4.Department of Abdominal Transplant Surgery,University Hospitals Leuven,Leuven,Belgium;5.Translational Metabolic Laboratory and Department of Paediatric Nephrology,Radboud University Medical Centre,Nijmegen,The Netherlands;6.Laboratory of Molecular and Cellular Signalling,KU Leuven,Leuven,Belgium |
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| Abstract: | Autophagy is the cell biology process in which cytoplasmic components are degraded in lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal cells such as podocytes and tubular epithelial cells and of immune cells. Recently, evidence is mounting that (dys)regulation of autophagy is implicated in the pathogenesis of various renal diseases, and might be an attractive target for new renoprotective therapies. In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases. |
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