| 阴性和阳性症状为主型精神分裂症患者脑部质子波谱与症状相关性 |
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| 引用本文： | 甘景梨,段惠峰,杨富增,杨家明,史振娟,张东卫,蒋战魁,祝希泉,王志娟.阴性和阳性症状为主型精神分裂症患者脑部质子波谱与症状相关性[J].临床精神医学杂志,2011,21(4):222-225. |
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| 作者姓名： | 甘景梨 段惠峰 杨富增 杨家明 史振娟 张东卫 蒋战魁 祝希泉 王志娟 |
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| 作者单位： | 1. 焦作,解放军第91中心医院全军精神疾病防治中心,河南,454003
2. 焦作,解放军第91中心医院医学影像中心,河南,454003 |
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| 摘 要： | 目的：比较阴性和阳性症状为主型精神分裂症患者前额叶和丘脑质子波谱及其与临床症状、执行功能的相关性方法：对61例阴性症状为主型精神分裂症患者（阴性组）和53例阳性症状为主型精神分裂症患者（阳性组）,在入组时应用抗精神病药治疗前与治疗后8周末,采用多体素磁共振质子波谱（1H-MRS）检测前额叶和丘脑N-乙酰基天门冬氨酸（NAA）与肌酸复合物（Cr）,计算NAA/Cr值;采用阳性和阴性症状量表（PANSS）和威斯康星卡片分类测验（WCST）评定临床症状和执行功能;进行两组1H-MRS、PANSS、WCST的比较与相关分析。结果：治疗前阴性组右侧丘脑NAA/Cr值（1.43±0.33）低于阳性组（1.58±0.35）,（t=2.35,P〈0.05）;治疗前阴性组分类数（1.68±0.54）低于阳性组（2.06±0.66）,（t=3.38,P〈0.01）,持续错误数（43.3±11.2）高于阳性组（31.8±9.22）,（t=5.95,P〈0.01）;治疗前阴性组左侧前额叶NAA/Cr值与阴性症状分、持续错误数呈负相关（r=-0.35,P〈0.05）;（r=-0.36,P〈0.01）。治疗前后阴性组左侧前额叶NAA/Cr值变化与阴性症状分变化、持续错误数变化呈负相关（r=-0.30,P〈0.05）;（r=-0.29,P〈0.05）,与分类数变化呈正相关（r=0.31,P〈0.05）。结论：不同亚型精神分裂症患者可能存在不同的神经生物学基础,阴性症状为主型精神分裂症患者左侧前额叶神经元的损害可能是引起阴性症状、执行功能障碍的生物学基础。
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| 关 键 词： | 精神分裂症 前额叶 丘脑 磁共振波谱 相关性 |
Relationship between metabolic measures of proton magnetic resonance spectroscopy in brain and symptoms of schizophrenics with negative and positive subtype |
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| GAN Jing-Li,DUAN Hui-feng,YANG Fu-zeng,YANG Jia-ming,SHI Zhen-juan,ZHANG Dong-Wei,JIANG Zhan-Kui,ZHU Xi-quan,WANG Zhi-juan.Relationship between metabolic measures of proton magnetic resonance spectroscopy in brain and symptoms of schizophrenics with negative and positive subtype[J].Journal of Clinical Psychological Medicine,2011,21(4):222-225. |
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| Authors: | GAN Jing-Li DUAN Hui-feng YANG Fu-zeng YANG Jia-ming SHI Zhen-juan ZHANG Dong-Wei JIANG Zhan-Kui ZHU Xi-quan WANG Zhi-juan |
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| Institution: | GAN Jing-Li,DUAN Hui-feng,YANG Fu-zeng,YANG Jia-ming,SHI Zhen-juan,ZHANG Dong-Wei,JIANG Zhan-Kui,ZHU Xi-quan,WANG Zhi-juan.Mental Diseases Prevention and Treatment Center of the Chinese PLA,PLA 91st Central Hospital,Jiaozuo 454003,China |
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| Abstract: | Objective:To compare the metabolic measures on prefrontal lobe and thalamus in negative subtype and positive subtype schizophrenics by proton magnetic resonance spectroscopy(1H-MRS),and to explore the relationship among metabolic measures,clinial symptom,and executive functioning.Method:61 negative subtype and 53 positive subtype schizophrenics were examined at prefrontal lobe and thalamus by multi-voxel 1H-MRS before antipsychotic treatment and at the end of 8-weeks' treatment.The N-acetylaspartate(NAA) an... |
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| Keywords: | schizophrenia prefrontal lobe thalamus magnetic resonance spectroscopy relationship |
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