| 内分泌干扰物诱导睾丸生精细胞凋亡的研究进展 |
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| 引用本文： | 王晟,秦达念.内分泌干扰物诱导睾丸生精细胞凋亡的研究进展[J].中华男科学杂志,2003,9(2):129-132. |
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| 作者姓名： | 王晟 秦达念 |
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| 作者单位： | 汕头大学医学院生理学教研室,广东,汕头,515031 |
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| 基金项目： | 广东省自然科学基金 ( 0 2 2 2 72 )，汕头大学研究与发展基金资助 |
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| 摘 要： | 睾丸生精细胞存在着自发性和化学物质诱发性凋亡。现代工业造成大量污染物涌入环境中 ,而这其中许多物质被证实具有生殖毒性 ,能够影响机体的生殖和发育。这类污染物被归属为内分泌干扰物 (EDCs EDs)。研究EDCs所诱导的生精细胞凋亡将丰富和拓展其甄别的依据及其途径 ,并对作用机制提出新的阐述 ,在生殖毒理学领域、男性生殖方面具有重要现实意义
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| 关 键 词： | 内分泌干扰物 生精细胞 凋亡 |
| 文章编号： | 1009-3591(2003)02-0129-04 |
| 修稿时间： | 2002年5月8日 |
The Involvement of Endocrine Disrupting Chemicals in Spermatogenic Cell Apoptosis |
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| Sheng WANG,Da Nian QIN.The Involvement of Endocrine Disrupting Chemicals in Spermatogenic Cell Apoptosis[J].National Journal of Andrology,2003,9(2):129-132. |
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| Authors: | Sheng WANG Da Nian QIN |
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| Institution: | Department of Physiology, Medical College of Shantou University, Shantou, Guangdong 515031, China. |
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| Abstract: | Elimination of spermatogenic cells via apoptosis occurs spontaneously under normal physiologic conditions and is often aggravated after chemical induced testicular impairment. A great amount of pollutants is released into the environment by modern industry, and many of these substances have been confirmed possessing reproductive toxicity, which can affect the reproduction and development of organism. These chemicals have been categorized to endocrine disrupting chemicals(EDCs). Studying spermatogenic cell apoptosis induced by EDCs will enrich and expand the pathway to identify EDCs, and will put forward new expounding of its mechanism. It has important meaning in the field of reproduction toxicology and male fertility. |
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| Keywords: | Endocrine disrupting chemicals Spermatogenic cells Apoptosis |
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