| 8-羟基脱氧鸟苷在早产儿喂养不耐受中的表达及意义 |
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| 引用本文： | 林金梅,赖兆新,熊佳华,黄鸣剑,黄绮文.8-羟基脱氧鸟苷在早产儿喂养不耐受中的表达及意义[J].中国当代医药,2014,0(17):179-180,183. |
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| 作者姓名： | 林金梅 赖兆新 熊佳华 黄鸣剑 黄绮文 |
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| 作者单位： | 林金梅 (广州莱德尔生物科技有限公司,广州,510330)； 赖兆新 (广州市海珠区妇幼保健院儿科,广州,510240)； 熊佳华 (广州市海珠区妇幼保健院儿科,广州,510240)； 黄鸣剑 (广州市海珠区妇幼保健院儿科,广州,510240)； 黄绮文 (广州市海珠区妇幼保健院儿科,广州,510240)； |
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| 摘 要： | 目的探讨8-羟基脱氧鸟苷（8-OHdG）在早产儿喂养不耐受患者中的表达和意义。方法将98例早产儿分为喂养不耐受组（48例）和对照组（50例），收集外周血和尿液，采用ELISA方法检测8-OHdG的表达。结果喂养不耐受组早产儿外周血8-OHdG，第1、7、14天尿8-OHdG的表达明显高于对照组，差异有统计学意义（P〈0．05）。结论应激（DNA氧化损伤）可能参与了早产儿喂养不耐受的发病，应激可能是早产儿喂养不耐受的发病机制之一；8-OHdG是评估早产儿喂养不耐受的参考指标。
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| 关 键 词： | 早产儿 喂养不耐受 应激 8-羟基脱氧鸟苷 |
Expression and significance of 8-OHdG in preterm infant with feeding intolerance |
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| Authors: | HUANG Qi-wen HUANG Ming-jian XIONG Jia-hua LAI Zhao-xin LIN Jin-mei |
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| Institution: | 1.Department of Pediatrics,Maternity and Child Health Care Hospital of Haizhu District in Guangzhou City,Guangzhou 518172,China;2.Rydell Biotechnology Co.,Ltd. in Guangzhou,Guangzhou 510330,China) |
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| Abstract: | Objective To explore the expression and significance of 8-Hydroxy-2＇-deoxyguanine （8-OHdG） in preterm infant with feeding intolerance. Methods 98 cases of preterm infant were divided into feeding intolerance group （48 cases） and control group （50 cases）,expression of 8-OHdG in peripheral blood and urine were measured by ELISA kit between feeding intolerance group and control group. Results 8-OHdG levels in peripheral blood and in urine at day 1,7,14 in feeding intolerance group was higher than that of control group,the difference was significant （P〈0.05）. Conclusion DNA oxidative injury might implicate in the pathogenesis of feeding intolerance in preterm infants,stress may be involved in feeding intolerance of preterm infants. 8-OHdG might be a useful parameter for monitoring feeding intoerance in preterm infant. |
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| Keywords: | Preterm infant Feeding intolerance Stress 8-Hydroxy-2＇-deoxyguanine |
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