| 降脂灵片对压力超负荷所致大鼠心肌肥厚的影响 |
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| 引用本文： | 秦泰春,顾振纶,刘世增.降脂灵片对压力超负荷所致大鼠心肌肥厚的影响[J].中成药,1999(Z1). |
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| 作者姓名： | 秦泰春 顾振纶 刘世增 |
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| 作者单位： | 苏州医学院!215007 |
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| 摘 要： | 大鼠腹主动 脉部分狭窄５ ｗ ｋ 后，形成实 验性心肌肥厚模 型，心肌和左心 室重量明 显增加； 心肌过 氧化脂质（ Ｌ Ｐ Ｏ） 含 量显著增加，超氧 化物歧 化酶（ Ｓ Ｏ Ｄ） 活性 下降；心 肌 Ｃａ２ ＋ 和主 动脉 Ｃａ２ ＋ 含量 明显增加，与模 型组相比 Ｐ＜ ０ ．０１ 。给降脂灵片０ ．３５ ｇ／ ｋｇ 和 ０ ．７ｇ／ ｋｇ 后均能降低心肌 和左心室重 量；降低心肌 Ｌ Ｐ Ｏ 含量，增加 Ｓ Ｏ Ｄ 活性；降 低心肌 Ｃａ２ ＋ 和主 动脉 Ｃａ２ ＋ 的含 量。提示降脂灵 片抗心 肌肥厚作用与清 除氧自由基和 钙拮抗有关
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| 关 键 词： | 降脂灵片 心肌 肥厚 氧自由基 钙 |
Effect of jiang zhi ling tablet on cardiac hypertrophy induced by pressure overload in rats. |
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| Qing TaiChun,Gu ZhenLun,Liu ShengZheng.Effect of jiang zhi ling tablet on cardiac hypertrophy induced by pressure overload in rats.[J].Chinese Traditional Patent Medicine,1999(Z1). |
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| Authors: | Qing TaiChun Gu ZhenLun Liu ShengZheng |
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| Abstract: | By coaraction of abdominal aorta induced cardiac hypertrophy in rats. The value of heart wet weight and left heart wet weight were significantly increased. The myocardium Lipiod Peroxidation(LPO) increased, Superoxide dismutase(SOD) decreased, the calcium contents of myocardium and aorta artery were also increased. After being treated with jiang zhi lin tablets 0.35 g/kg and 0.7g/kg for five weeks, the heart wet weight and left heart wet weight were significantly decreased. The myocardium LPO decreased, SOD increased. The calcium contents of myocardium and aorta artery were also decreased. The effect of jiang zhi lin tablets on preventing cardiac hypertrophy may be related to cleaning oxygen free radicals and resistance to calcium. |
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| Keywords: | jiang zhi ling tablet Cardiac hypertrophy Oxygen free radicals Calcium |
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