Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family. |
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| Authors: | K F Leung W Y Au A Y Chan L C Chan J S Waye D H Chui S K Ma |
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| Affiliation: | Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China. |
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| Abstract: | A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS. |
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