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Glucose-6-Phosphate Dehydrogenase Status and Risk of Hemolysis in Plasmodium falciparum-Infected African Children Receiving Single-Dose Primaquine |
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| Authors: | Alice C. Eziefula Helmi Pett Lynn Grignard Salome Opus Moses Kiggundu Moses R. Kamya Shunmay Yeung Sarah G. Staedke Teun Bousema Chris Drakeley |
| Affiliation: | aFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom;bDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands;cInfectious Diseases Research Collaboration, Kampala, Uganda;dDepartment of Medicine, Makerere University College of Health Sciences, Kampala, Uganda |
| Abstract: | Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A− heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed. |
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