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Case Report and Cohort Analysis of Drug-Induced Liver Injury Associated with Daptomycin
Authors:Nicole Bohm  Charles Makowski  Mario Machado  Adam Davie  Nelson Seabrook  Lee Wheless  Benjamin Bevill  Bradley Clark  T. Rogers Kyle  III
Abstract:A patient receiving daptomycin developed asymptomatic transaminitis and hyperbilirubinemia without concurrent multiorgan dysfunction or elevation of his creatinine kinase level. After ruling out other etiologies, the liver injury was attributed to daptomycin and was subsequently resolved. A single-center retrospective cohort analysis of baseline and follow-up liver function panels (n = 614) from all admissions from 2008 to 2013 during which daptomycin was administered did not reveal any other cases of probable or definite drug-induced liver injury associated with daptomycin.
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