Affiliation: | †Departments of Medicinal Chemistry, ‡Preclinical Drug Safety, §Molecular Pharmacology, ∥Pain Pharmacology, ⊥Pharmacokinetics, and #Discovery Informatics, Global Drug Discovery, Grünenthal Innovation, Grünenthal GmbH, D-52099 Aachen, Germany;○ASCAGmbH Angewandte Synthesechemie Adlershof, Magnusstr. 11, 12489 Berlin, Germany |