Randomized Clinical Trial To Evaluate the Immunogenicity of Quadrivalent Meningococcal Conjugate and Polysaccharide Vaccines in Adults in the United Kingdom |
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| Authors: | Maheshi N. Ramasamy Elizabeth A. Clutterbuck Kathryn Haworth Jaclyn Bowman Omar Omar Amber J. Thompson Geraldine Blanchard-Rohner Ly-Mee Yu Matthew D. Snape Andrew J. Pollard |
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| Affiliation: | aOxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom;bCentre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom;cDepartment of Paediatrics, Children''s Hospital of Geneva, Geneva, Switzerland |
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| Abstract: | Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. {"type":"clinical-trial","attrs":{"text":"NCT00901940","term_id":"NCT00901940"}}NCT00901940.) |
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