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Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension
Affiliation:1. Yale University, New Haven, CT;2. Inselspital, University of Bern, Berne, Switzerland;3. Hospital Clinic-IDIBAPS-Ciberehd, University of Barcelona, Barcelona, Spain;4. Inland Empire Liver Foundation, Rialto, CA;5. Pinnacle Clinical Research, San Antonio, TX;6. Duke University, Durham, NC;7. Texas Liver Institute, University of Texas Health San Antonio, San Antonio, TX;8. Methodist University Hospital, University of Tennessee Health Sciences Center, Memphis, TN;9. Indiana University, Indianapolis, IN;10. Bon Secours Liver Institute, Richmond, VA;11. Gastro One, Germantown, TN;12. Mercy Medical Center and University of Maryland School of Medicine, Baltimore, MD;13. Hospital Ramon y Cajal, University of Alcala, IRYCIS, CIBEREHD, Madrid, Spain;14. Conatus Pharmaceuticals Inc., San Diego, CA;15. Virginia Commonwealth University, Richmond, VA;1. Swiss Liver Center, Department of Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital, Switzerland;3. Department of Biomedical Research, University of Bern, Bern, Switzerland;4. Institute for Pathology, University of Bern, Bern, Switzerland;1. Sezione di Gastroenterologia e Epatologia, Di.Bi.M.I.S, Università di Palermo, Italy;2. Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC, Canada;3. Division of Gastroenterology, Department of Medical Sciences, University of Torino, Torino, Italy;4. Hepatology Unit, Ospedale San Giuseppe, University of Milan, Milan, Italy;5. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong;6. Swiss Liver Center, Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland;7. Department of Pathophysiology and Transplantation, Ca'' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy;8. Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom;9. Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom;10. Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Italy;11. Research Center DENOTHE, University of Florence, Italy;12. Centre d’Investigation de la Fibrose Hépatique, INSERM U1053, Hôpital Haut-Lévêque, Bordeaux University Hospital, Pessac, France;1. Saint Louis University, St Louis, MO, USA;2. University of California San Diego, La Jolla, CA, USA;3. Virginia Commonwealth University, Richmond, VA, USA;4. Columbia University, New York, NY, USA;5. Johns Hopkins University, Baltimore, MD, USA;6. Duke University, Durham, NC, USA;7. Indiana University, Indianapolis, IN, USA;8. Cleveland Clinic, Cleveland, OH, USA;9. University of California San Francisco, San Francisco, CA USA;10. Virginia Mason Medical Center, Seattle, WA, USA;11. Case Western Reserve University, Cleveland, OH, USA;12. Washington University, St Louis, MO, USA;13. The National Cancer Institute, Bethesda, MD, USA;14. The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA;2. Clinical Outcomes Solutions, Folkestone, UK;3. Vectura Group PLC, Chippenham, UK;4. Department of Gastroenterology, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK;5. Liver Unit, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK;11. Department of Medicine, University of Louisville School of Medicine, Louisville, USA;12. Conatus Pharmaceuticals Inc., San Diego, USA;1. CHESS Group, Hepatic Hemodynamic Lab, Institute of Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China;2. CHESS Frontier Center, Lanzhou University, Lanzhou, China;3. Hepatology Group, Swiss Liver Center, University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland;4. GI/Liver Unit, Institute of Digestive Diseases and Metabolism, Hospital Clinic, University of Barcelona, Barcelona, Spain;5. Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
Abstract:
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  • Keywords:Non-alcoholic steatohepatitis  Cirrhosis  Portal hypertension  Portal pressure  Hepatic venous pressure gradient  HVPG  Emricasan  Caspase inhibition  RCT
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