| 灯盏花素对糖尿病大鼠肾小球NO／NOS的影响 |
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| 引用本文： | 唐先格,张颜波,万桂玲,东野光.灯盏花素对糖尿病大鼠肾小球NO／NOS的影响[J].中华糖尿病杂志,2009,17(1):70-71. |
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| 作者姓名： | 唐先格 张颜波 万桂玲 东野光 |
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| 作者单位： | 唐先格,张颜波,东野光(泰山医学院附属医院内分泌科,山东泰安,271000);万桂玲(临沂市肿瘤医院综合内科)
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| 摘 要： | 成年健康雄性Wistar大鼠随机分为正常对照（NC）gi、糖尿病（DM）组、灯盏花素（EB）组，每组24只。成模2和8周后，分别测定内生肌酐清除率、尿白蛋白、肾重／体重、肾小球PKC活性、NO和NOS含量。发现灯盏花素对糖尿病肾病有保护作用，并可能通过抑制PKC的活性影响NO／NOS。
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| 关 键 词： | 糖尿病 蛋白激酶C 灯盏花素 肾小球 一氧化氮 一氧化氮合酶 |
Effect of erigeron breviscapus on NO/NOS in glomeruli of diabetic rats |
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| Institution: | TANG Xian-ge, ZHANG Yan- bo, WAN Gui-ling, et al.( Department of Endocrinology, Affiliated Hospital of Taishan Medical College, Tai＇an 271000, China) |
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| Abstract: | Adult healthy male Wistar rats were divided into 3 groups randomly： normal control group（NC）; diabetes group（DM） and erigeron breviscapus group（EB）. The changes in creatinine clearance rate（Ccr）, urinary albumin, kidney weight to body weight ratio, activity of PKC,content of NO and NOS were observed after two and eight weeks. In conclusion, Erigeron breviscapus plays an important protective role in diabetic nephropathy. Erigeron breviscapus may influence the expression of NO and NOS through inhibiting PKC. |
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| Keywords: | Diabetes Protein kinase C Erigeron breviscapus Glomerulus Nitric oxide Nitric-oxide synthase |
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