| GC法检测盐酸法舒地尔中有机溶剂残留量 |
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| 引用本文： | 陈晶晶,雷咪,干伟,杨敏. GC法检测盐酸法舒地尔中有机溶剂残留量[J]. 中国药师, 2012, 15(3): 365-367 |
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| 作者姓名： | 陈晶晶 雷咪 干伟 杨敏 |
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| 作者单位： | 湖北中医药大学药学院 武汉430065 |
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| 摘 要： | 目的:建立盐酸法舒地尔原料药中残留溶剂的气相色谱测定方法.方法:甲醇、二氯甲烷、叔丁基甲基醚(MTBE)采用顶空进样法进行检测,N,N-二甲基甲酰胺( DMF)采用直接进样法检测.结果:各组分完全分离,线性关系良好(r≥0.9996),平均回收率为89.6％～110.5％.结论:该方法适用于盐酸法舒地尔原料药中残留溶剂的测定,操作简便、结果准确、灵敏度高、重复性好.
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| 关 键 词： | 气相色谱法 有机残留溶剂 自动顶空进样 直接进样 |
| 收稿时间： | 2011-09-27 |
| 修稿时间： | 2011-12-13 |
Determination of Residual Solvents in Fasudil Hydrochloride by GC |
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| Chen Jingjing,Lei Mi,Gan Wei and Yang Min. Determination of Residual Solvents in Fasudil Hydrochloride by GC[J]. China Pharmacist, 2012, 15(3): 365-367 |
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| Authors: | Chen Jingjing Lei Mi Gan Wei Yang Min |
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| Affiliation: | College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065;College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065;College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065;College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065 |
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| Abstract: | Objective：To establish a method to determine the residual solvents in fasudil hydrochloride.Method：Methanol, methylene chloride,methyl tert-butyl ether and dimethyl formamide were determined by head-space GC while DMF was determined by direct injection.Result：All the solvents could be completely separated with good linear relationships（r≥0.999 6）.The average recovery was within the range of 89.6%-110.5%.Conclusion：The method can be used in the determination of the residual solvents in fasudil hydrochloride with the properties of simple,accurate,sensitive and repeatable. |
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| Keywords: | GC Residual solvents Head-space gas chromatography Direct injection |
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