|
|||||
|
|
Essential tremor is not associated with alpha-synuclein gene haplotypes. |
|
| Authors: | Simona Pigullo Emilio Di Maria Roberta Marchese Emilia Bellone Rossella Gulli Cesa Scaglione Stella Battaglia Paolo Barone Paolo Martinelli Giovanni Abbruzzese Franco Ajmar Paola Mandich |
| Affiliation: | Department of Neurosciences, Ophthalmology and Genetics-Section of Medical Genetics, University of Genova, Genova, Italy. |
| Abstract: | A specific allele of the NACP-Rep1 polymorphism within the alpha-synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the alpha-synuclein gene. Our results did not confirm the association reported previously and failed to identify a alpha-synuclein specific haplotype as susceptibility factor for essential tremor. |
| Keywords: | essential tremor ET α‐synuclein NACP association study |