Common problems with antiretroviral therapy among three Swedish groups of HIV infected individuals |
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Authors: | Amadou Jallow Sofia K?lvemark Sporrong Lilian Walther-Jallow Peter M. Persson Urban Hellgren ?rjan Ericsson |
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Affiliation: | (1) Apoteket K?llan, Box 64, 14501 Norsborg, Sweden;(2) Apoteket AB, 131 88 Stockholm, Sweden;(3) Department of Medicine, Center for Infectious Medicine, Karolinska Institute, Karolinska University Hospital, 141 86 Huddinge, Stockholm, Sweden;(4) Hospital Pharmacy, Karolinska University Hospital, 141 86 Huddinge, Stockholm, Sweden;(5) Unit of Infectious Diseases, Karolinska University Hospital, 141 86 Huddinge, Stockholm, Sweden;(6) Department of Health and Medical Services, The National Board of Health and Welfare, 106 30 Stockholm, Sweden |
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Abstract: | Objective The main objective of this study was to identify and compare the common problems and difficulties associated with combination antiretroviral therapy (CART) as experienced by three major groups of HIV infected individuals (homo- or bisexuals, former injecting drug users and origins of Sub-Saharan Africa) in Sweden. Methods Based on the results from in-depth interviews with 15 representatives from the three major groups, a questionnaire was designed for use in a problem detection study (PDS). The study was conducted with 195 HIV-positive patients residing in the major cities of Sweden. Results The overall response rate was 79%. The problems identified in all three groups were negative attitudes from the public, worries about disease progression or therapy failure, medication or drug-related problems and problems in connection to pharmacy visits. A specific problem in the homo- or bisexual group was drug-related problems such as adverse effects, drug interactions and pill burden. For former injecting drug users, the specific problem was disease-related conflicts with relatives and the problem of coping with the social and psychological burden caused by the HIV infection. The African group termed the risk of exposing their medication at the pharmacy as a specific problem, as this could reveal their HIV status. Conclusions Our findings regarding problems with CART in three patient groups in Sweden may be of use to tailor pharmacy care to HIV infected individuals. General strategies to improve adherence need to be complemented with approaches that will address the specific needs for the different patient groups affected by HIV. Further studies on group-specific interventions that promote concordance and adherence to CART will be necessary to minimize therapy failure and viral resistance. |
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Keywords: | Adherence AIDS Antiretroviral therapy Concordance Drug-related problems Drug-use problems HIV Patient counselling Sweden |
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