| 雷公藤多甙影响蟾蜍神经-肌接头传递初探 |
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| 引用本文： | 吕广能,周玲,徐建国. 雷公藤多甙影响蟾蜍神经-肌接头传递初探[J]. 四川大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 吕广能 周玲 徐建国 |
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| 作者单位： | 基础医学院生理学教研室 |
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| 摘 要： | 用微电极细胞内记录终板电位（ＥＰＰ）的电生理学方法，在２０只成年蟾蜍的坐骨神经－缝匠肌标本上研究了雷公藤多甙（ＴＷＰ）对神经肌接头（ＮＭＪ）兴奋传递的影响。结果表明：ＴＷＰ可引起ＥＰＰ振幅改变，影响ＮＭＪ的兴奋传递，而且其影响具有明显的量效依赖关系，适当浓度的ＴＷＰ能明显地增加ＥＰＰ振幅，促进ＮＭＪ的兴奋传递。
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| 关 键 词： | 雷公藤多甙 终板电位 蟾蜍 |
The Effects of Tripterygium Wilfordii Polyglycosidium on Neuromuscular Junctions of Adult Toad |
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| Affiliation: | Chengdu 610041 |
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| Abstract: | The effects of tripterygium wilfordii polyglycosidium(TWP) on the transmission at the neuromuscular junctions (NMJ) of sciatic nerve sartorius muscle preparations of 20 adult toads (Bufo bufo gargarizans) in vitro were studied by means of intracellular microelectrode recording of endplate potentials (EPP). The results revealed that TWP could cause changes of EPP amplitude so as to influence the transmission at NMJ, and the effects apparently depended on the concentration of the drug. A proper concentration of TWP could produce a significant increase in EPP amplitude and therefore facilitate the transmission at the NMJ. |
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| Keywords: | Tripterygium wilfordii polyglycosidium End plate potential Toad |
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