热疗联合大剂量甘露聚糖肽胸腔注射治疗恶性胸腔积液的临床观察

目的：观察热疗联合大剂量甘露聚糖肽胸腔注射治疗恶性胸腔积液的临床疗效。方法：将36例恶性胸腔积液患者随机分为两组，采用胸腔闭式引流尽可能排尽胸腔积液后，治疗组18例用大剂量甘露聚糖肽胸腔注射后行射频热疗，对照组18例单用大剂量甘露聚糖肽胸腔注射治疗，比较两组的疗效、生活质量改善率和毒副反应。结果：治疗组和对照组治疗有效率分别为88.9%和66.7%，差异有统计学意义（P<0.05）；两组治疗前后生活质量改善率的差异没有统计学意义（P>0.05）；热疗主要的毒副反应为皮下脂肪硬结、局部皮肤灼伤。结论：热疗联合大剂量甘露聚糖肽胸腔注射治疗恶性胸腔积液疗效满意，毒副反应可以耐受，值得临床推广。

Clinical observa tion of thermotherapy combined with intra-pleural injection of high dose mannatide in the treating of malignant pleural effusion

Objective:To study the clinical efficacy, the change of KPS score and side effects induced by thermotherapy combined with intra-pleural injection of high dose mannatide in the treating of malignant pleural effusion. Methods:Thirty-six patients with malignant pleural effusion were randomized into groups after closed drainage. The 18 patients in the observation group were treated with intra-pleural injection of high dose mannatide, and then underwent thermotherapy. The 18 patients in the control group were treated with intra-pleural injection of high dose mannatide. The clinical efficacy, the change of karnofsky (KPS) score and side effects were compared between the groups. Results:The response rate in the observation group was 88.9%, and 66.7% in the control group. There was significant difference between the groups (P<0.05).The difference was not significant in the change of KPS score before and after treatment between two groups (P>0.05). The main toxicities of thermotherapy were induration of subcutaneous fat and local skin scorch. Conclusion:Thermotherapy combined with intra-pleural injection of high dose mannatide can increase efficacy in the treating of malignant pleural effusion, and the toxicity can be tolerated,it was worthy for clinical use.