Histology of the intestinal peritoneum in patients with cirrhosis of the liver and ascites |
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Authors: | Dr Ivo Buhac MD ScD John Jarmolych MD |
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Institution: | (1) Medical Service, Veterans Administration Hospital, 12208 Albany, New York;(2) Department of Medicine, Albany Medical College, 12208 Albany, New York |
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Abstract: | Portal hypertension and hypoalbuminemia are usually incriminated in the development of ascites in liver cirrhosis, and altered peritoneal permeability is considered only as a hypothetical possibility. Jejunal postmortem specimens were studied in 15 control patients and 16 patients dying with cirrhosis of the liver and ascites. In decompensated cirrhosis a fibrous thickening of the peritoneum was found, 159.0±96.4 m (mean±sd) compared to 24.5±10.6 m in controls (P<0.001). An increase in the size and number of blood vessels, lymphangiectasiae, and mononuclear cell infiltration were invariably present. These histological changes are consistent with a nonspecific chronic peritonitis. The findings indicate there is increased blood perfusion and lymph flow within the intestinal peritoneum in patients with decompensated cirrhosis of the liver and support the existence of an intestinal peritoneal factor in the pathogenesis of cirrhotic ascites. |
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