辛苍汤对小儿支气管哮喘缓解期慢性气道炎症的治疗作用

目的:通过临床研究,观察辛苍汤对小儿支气管哮喘缓解期慢性气道炎症的治疗作用.方法:将60例哮喘缓解期患儿分为两组,辛苍汤口服治疗组和酮替芬口服对照组各30例.临床治疗3个月后,观察患儿疗效和外周血嗜酸性粒细胞绝对计数(eosinophil,EOS)、血清免疫球蛋白E(immunoglobulin E,IgE)、血清白细胞介素-4(interleukin 4,IL-4)、白细胞介素-5(interleukin 5,IL-5)及肺功能的变化.结果:治疗组有效率为83.3%,对照组为80.0%,两组无显著性差异(P＞0.05).治疗组EOS、IL-5浓度明显下降,与对照组比较均有显著性差异(P＜0.05).治疗组第1秒钟用力呼气容积(forced expiratory volume inone second,FEV1)明显改善,优于对照组(P＜0.05).结论:由祛风药辛夷和苍耳子组成的辛苍汤治疗哮喘缓解期慢性气道炎症,具有降低外周血嗜酸性粒细胞浓度和血清IL-5浓度、降低气道阻力的作用.

Therapeutic effect of Xincang Decoction on chronic airway inflammation in children with bronchial asthma in remission stage

OBJECTIVE: To observe the therapeutic effect of Xincang Decoction on chronic airway inflammation in children with asthma in clinical investigation. METHODS: Xincang Decoction was composed of Flos Magnoliae (Xinyi) and Fructus Xanthii (Cangoerzi), the traditional Chinese herbs for expelling wind. Sixty cases of children with bronchial asthma in remission stage were randomly divided into two groups. Thirty cases in the treatment group were treated with Xincang Decoction and the others in the control group were treated with ketotifen fumarate. The therapeutic effects of the two groups were compared, and the peripheral eosinophil (EOS) count, the levels of immunoglobulin E (IgE), interleukin 4 (IL-4) and interleukin 5 (IL-5), and the pulmonary functions were observed before and three months after the treatment. RESULTS: After three months treatment, the results showed that the total response rates of the treatment and the control group were 83.3% and 80.0%, respectively, without marked difference (P>0.05). The levels of EOS and IL-5 were obviously decreased after the treatment, and the levels of EOS and IL-5 of the patients in the treatment group were lower than those in the control group (P<0.05). Meanwhile the forced expiratory volume in one second (FEV(1)) was improved after the treatment, and the FEV(1) of the patients in the treatment group was higher than that of the patients in the control group (P<0.05). CONCLUSION: Xincang Decoction can decrease the levels of EOS and IL-5 and improve the pulmonary function in treating chronic airway inflammation in children with bronchial asthma in remission stage.