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Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature |
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| Authors: | Klaartje van Engelen Johannes H. M. Merks Jan Lam Leontien C. M. Kremer Manouk Backes Marieke J. H. Baars Heleen J. H. van der Pal Alex V. Postma Rogier Versteeg Huib N. Caron Barbara J. M. Mulder |
| Affiliation: | 1. Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands 2. Department of Clinical Genetics, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands 3. Department of Paediatric Oncology, Academic Medical Centre, Amsterdam, The Netherlands 4. Department of Paediatric Cardiology, Academic Medical Centre, Amsterdam, The Netherlands 5. Outpatient Clinic for the Late Effects of Treatment for Childhood Cancer, Academic Medical Centre, Amsterdam, The Netherlands 6. Cochrane Childhood Cancer Group, Academic Medical Centre, Amsterdam, The Netherlands 7. Heart Failure Research Centre, Department of Anatomy and Embryology, Academic Medical Centre, Amsterdam, The Netherlands 8. Department of Human Genetics, Academic Medical Centre, Amsterdam, The Netherlands 9. Department of Cardiology, University Medical Centre, Utrecht, The Netherlands |
| Abstract: | Data on the prevalence of congenital heart defects (CHD) in neuroblastoma patients are inconsistent. If CHD are more common in neuroblastoma patients than in the general population, cardiac screening might be warranted. In this study we used echocardiography to determine the prevalence of CHD in a single centre cohort of surviving neuroblastoma patients. In addition, we performed a systematic review of the literature. Echocardiography was performed in 119 of 133 patients (89.5%). Only two patients (1.7%) had CHD. The prevalence of CHD was not significantly different from a previously published control group of 192 leukaemia patients examined by echocardiography (P = 0.49). Literature search revealed 17 studies, showing prevalence rates of CHD in neuroblastoma patients ranging from 0 to 20%. Prevalence was less than 3.6% in the majority of studies. Most studies lacked information on validity. We conclude that current evidence does not support standard cardiac screening in all patients with neuroblastoma. |
| Keywords: | Neuroblastoma Congenital heart defects Echocardiography Association Screening Neural crest |
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