中西医结合治疗空洞性肺结核临床对照研究

目的:探讨中西医结合疗法治疗空洞性肺结核的临床疗效。方法:2007年10月～2009年2月期间,签署知情同意书后,根据患者意愿将就诊的空洞性肺结核患者分为治疗组(40例)和对照组(35例),两组均按标准化疗方案服用抗结核药物,治疗组加服加味百合固金汤,疗程6个月。主要观察治疗前后的胸部CT、痰涂片变化。结果:(1)两组病例均未发生脱落现象。(2)两组总有效率分别为97.5%(39/40)、68.6%(24/35),治疗组能显著提高临床疗效,χ2=13.058,P=0.001。(3)治疗组明显能促进空洞闭合,χ2=7.589,P=0.022。(4)治疗组能显著促进结核病灶的吸收,χ2=7.254,P=0.027。(5)治疗组提高初治、复治病例痰涂片转阴率,但两组相比无统计学意义,P=1.000。结论:中西医结合疗法能显著提高空洞性肺结核临床疗效,促进空洞闭合及结核病灶的吸收。

The Controlled Clinical Trial of Cavitary Pulmonary Tuberculosis Treated by Traditional Chinese and Western Medicine

Objective：To investigate the therapeutic effect of treating Cavitary Pulmonary Tuberculosis with the therapy of combining traditional Chinese and western medicine.Methods：75 Patients with computerized tomography proven cavitary pulmonary tuberculosis were enrolled in this study from October,2007 to February, 2009 in Infectious Diseases Unit of People＇ s Hospital of Macheng City, Hubei Province. After giving written consensus, patients were divided into therapy group （n=40） or control group （n=35） by their intentions. Patients in both groups received standard therapeutic regimen of tuberculosis. Meanwhile, therapy group received traditional chinese medicine, modified Baihegujin Decoction. All patients were received 6 months treatment.Computerized tomography, acid fast stain test of sputum were examined before and after treatment,separately. Results：There were no patients of both group dropping out in 6 months period of treatment. The total effective rates in therapy group was 97.5% （39/40）, and in control group was 68.6% （24/35）,the difference between the two group was significant （x2=13.058, P =0.001）.The precipitate cavitary dininishedly the difference between the two group was significant（X2=7.589, P =0.022）,The resorption of focus of infection,the difference between the two group was significant（x2=7.254, P =0.027）.Conclusion：Therapy of combining traditional Chinese and western medicine in cavitary pulmonary tuberculosis could improve therapeutic effect, precipitate eavitary diminishedly and resorption of focus of infection.